%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ahuka-Mundeke, S.
%A Ayouba, Ahidjo
%A Mbala-Kingebeni, P.
%A Liégeois, Florian
%A Esteban, Amandine
%A Lunguya-Metila, O.
%A Demba, D.
%A Bilulu, G.
%A Mbenzo-Abokome, V.
%A Inogwabini, B. I.
%A Muyembe-Tamfum, J. J.
%A Delaporte, Eric
%A Peeters, Martine
%T Novel multiplexed HIV/Simian immunodeficiency virus antibody detection assay
%D 2011
%L fdi:010054236
%G ENG
%J Emerging Infectious Diseases
%@ 1080-6040
%M ISI:000297874400013
%N 12
%P 2277-2286
%R 10.3201/eid1712.110783
%U https://www.documentation.ird.fr/hor/fdi:010054236
%> https://www.documentation.ird.fr/intranet/publi/2011/12/010054236.pdf
%V 17
%W Horizon (IRD)
%X Like most emerging infectious disease viruses, HIV is also of Zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of the Congo, we collected 330 samples derived from nonhuman primate bushmeat at 3 remote forest sites. SIV prevalences were estimated by using a novel high-throughput assay that included 34 HIV and SIV antigens in a single well. Overall, 19% of nonhuman primate bushmeat was infected with SIVs, and new SIV lineages were identified. Highest SIV prevalences were seen in red-tailed guenons (25%) and Tshuapa red colobus monkeys (24%), representing the most common hunted primate species, thus increasing the likelihood for cross-species transmission. Additional studies are needed to determine whether other SIVs crossed the species barrier. With the newly developed assay, large-scale screening against many antigens is now easier and faster.
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