Ahuka-Mundeke S., Ayouba Ahidjo, Mbala-Kingebeni P., Liégeois Florian, Esteban Amandine, Lunguya-Metila O., Demba D., Bilulu G., Mbenzo-Abokome V., Inogwabini B. I., Muyembe-Tamfum J. J., Delaporte Eric, Peeters Martine. (2011). Novel multiplexed HIV/Simian immunodeficiency virus antibody detection assay. Emerging Infectious Diseases, 17 (12), p. 2277-2286. ISSN 1080-6040.
Titre du document
Novel multiplexed HIV/Simian immunodeficiency virus antibody detection assay
Année de publication
2011
Auteurs
Ahuka-Mundeke S., Ayouba Ahidjo, Mbala-Kingebeni P., Liégeois Florian, Esteban Amandine, Lunguya-Metila O., Demba D., Bilulu G., Mbenzo-Abokome V., Inogwabini B. I., Muyembe-Tamfum J. J., Delaporte Eric, Peeters Martine
Source
Emerging Infectious Diseases, 2011,
17 (12), p. 2277-2286 ISSN 1080-6040
Like most emerging infectious disease viruses, HIV is also of Zoonotic origin. To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of the Congo, we collected 330 samples derived from nonhuman primate bushmeat at 3 remote forest sites. SIV prevalences were estimated by using a novel high-throughput assay that included 34 HIV and SIV antigens in a single well. Overall, 19% of nonhuman primate bushmeat was infected with SIVs, and new SIV lineages were identified. Highest SIV prevalences were seen in red-tailed guenons (25%) and Tshuapa red colobus monkeys (24%), representing the most common hunted primate species, thus increasing the likelihood for cross-species transmission. Additional studies are needed to determine whether other SIVs crossed the species barrier. With the newly developed assay, large-scale screening against many antigens is now easier and faster.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010054236]
Identifiant IRD
fdi:010054236
