@article{fdi:010054226,
  title = {{I}nfections in infants during the first 12 months of life : role of placental malaria and environmental factors},
  author = {{L}e {P}ort, {A}. and {W}atier, {L}. and {C}ottrell, {G}illes and {O}u{\'e}draogo, {S}. and {D}echavanne, {C}. and {P}ierrat, {C}. and {R}achas, {A}. and {B}ouscaillou, {J}. and {B}ouraima, {A}. and {M}assougbodji, {A}. and {F}ayomi, {B}. and {T}hi{\'e}baut, {A}. and {C}handre, {F}abrice and {M}igot {N}abias, {F}lorence and {M}artin-{P}r{\'e}vel, {Y}ves and {G}arcia, {A}ndr{\'e} and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he association between placental malaria ({PM}) and first peripheral parasitaemias in early infancy was assessed in {T}ori {B}ossito, a rural area of {B}enin with a careful attention on transmission factors at an individual level. {M}ethodology: {S}tatistical analysis was performed on 550 infants followed weekly from birth to 12 months. {M}alaria transmission was assessed by anopheles human landing catches every 6 weeks in 36 sampling houses and season defined by rainfall. {E}ach child was located by {GPS} and assigned to the closest anopheles sampling house. {D}ata were analysed by survival {C}ox models, stratified on the possession of insecticide-treated mosquito nets ({ITN}s) at enrolment. {P}rincipal {F}indings: {A}mong infants sleeping in a house with an {ITN}, {PM} was found to be highly associated to first malaria infections, after adjusting on season, number of anopheles, antenatal care ({ANC}) visits and maternal severe anaemia. {I}nfants born from a malaria infected placenta had a 2.13 fold increased risk to present a first malaria infection than those born from a non infected placenta ([1.24-3.67], p<0.01) when sleeping in a house with an {ITN}. {T}he risk to present a first malaria infection was increased by 3.2 to 6.5, according to the level of anopheles exposure (moderate or high levels, compared to the absence of anopheles). {C}onclusions: {F}irst malaria infections in early childhood can be attributed simultaneously to both {PM} and high levels of exposure to infected anopheles. {P}rotective measures as {I}ntermittent {P}reventive {T}reatment during pregnancy ({IPT}p) and {ITN}s, targeted on both mothers and infants should be reinforced, as well as the research on new drugs and insecticides. {I}n parallel, investigations on placental malaria have to be strengthened to better understand the mechanisms involved, and thus to protect adequately the infants high risk group.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {6},
  numero = {11},
  pages = {e27516},
  ISSN = {1932-6203},
  year = {2011},
  DOI = {10.1371/journal.pone.0027516},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054226},
}