@article{fdi:010054204,
  title = {{A}ssessment of exposure to {P}lasmodium falciparum transmission in a low endemicity area by using multiplex fluorescent microsphere-based serological assays},
  author = {{S}arr, {J}ean {B}irame and {O}rlandi-{P}radines, {E}. and {F}ortin, {S}onia and {S}ow, {C}. and {C}orn{\'e}lie, {S}ylvie and {R}ogerie, {F}. and {G}uindo, {S}. and {K}onate, {L}. and {F}usai, {T}. and {R}iveau, {G}. and {R}ogier, {C}. and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}he evaluation of malaria transmission intensity is a crucial indicator for estimating the burden of malarial disease. {I}n this respect, entomological and parasitological methods present limitations, especially in low transmission areas. {T}he present study used a sensitive multiplex assay to assess the exposure to {P}lasmodium falciparum infection in children living in an area of low endemicity. {I}n three {S}enegalese villages, specific antibody ({I}g{G}) responses to 13 pre-erythrocytic {P}. falciparum peptides derived from {L}sa1, {L}sa3, {G}lurp, {S}alsa, {T}rap, {S}tarp, {C}sp and {P}f11.1 proteins were simultaneously evaluated before ({J}une), at the peak ({S}eptember) and after ({D}ecember) the period of malaria transmission, in children aged from 1 to 8 years. {R}esults: {C}ompared to other antigens, a high percentage of seropositivity and specific antibody levels were detected with {G}lurp, {S}alsa1, {L}sa3{NR}2, and {L}sa1{J} antigens. {T}he seropositivity increased with age for all tested antigens. {S}pecific {I}g{G} levels to {G}lurp, {S}alsa1, {L}sa3{NR}2, and {L}sa1{J} were significantly higher in {P}. falciparum infected children compared to non-infected and this increase is significantly correlated with parasite density. {C}onclusion: {T}he multiplex assay represents a useful technology for a serological assessment of rapid variations in malaria transmission intensity, especially in a context of low parasite rates. {T}he use of such combined serological markers (i.e. {G}lurp, {L}sa1, {L}sa3, and {S}alsa) could offer the opportunity to examine these variations over time, and to evaluate the efficacy of integrated malaria control strategies.},
  keywords = {},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {4},
  numero = {},
  pages = {212},
  ISSN = {1756-3305},
  year = {2011},
  DOI = {10.1186/1756-3305-4-212},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054204},
}