@article{fdi:010054197,
  title = {{I}ndividual host factors associated with {O}nchocerca volvulus microfilarial densities 15, 80 and 180 days after a first dose of ivermectin},
  author = {{P}ion, {S}{\'e}bastien and {G}rout, {L}. and {K}amgno, {J}. and {N}ana-{D}jeunga, {H}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{R}eduction in {O}nchocerca volvulus skin microfilarial densities after treatment with ivermectin shows wide between-host variation. {D}ata from two separate studies conducted in {C}ameroon on onchocerciasis patients treated for the first time with ivermectin were analyzed to identify host factors associated with microfilarial density at different time-points after treatment. {I}n one site ({N}kam valley), the dataset included 103 adult males for whom age, number of palpable onchocercal nodules and microfilarial densities on {DO} (pre-treatment), {D}15, {D}80 and {D}180 were available. {I}n the other site ({V}ina valley), analyses were conducted on 965 individuals of both sexes aged 5 years and over; in this dataset, available information included age, gender, exact dose of ivermectin received, onchocerciasis endemicity level in the village of residence and microfilarial densities on {DO} and {D}180. {N}egative binomial regression models of microfilarial density at the different intervals post-treatment were fitted, using maximum likelihood, with the available independent variables. {G}ender and age were found to be associated with microfilarial density on {D}180. {T}he initial microfilarial density influenced post-treatment densities at all the time-points. {A}ll other things being equal, microfilarial densities on {D}180 were higher in individuals harbouring a higher number of nodules or living in communities with high endemicity levels. {T}his study demonstrates that {O}. volvulus microfllarial density measured after a first treatment with ivermectin, and thus probably the rate of skin repopulation by microfilariae (mf) varies according to several host factors. {S}hould such factors also influence ivermectin efficacy after repeated treatment, then they should be taken into account to determine whether sub-optimal responses to treatment reported from various areas in {A}frica are actually due to parasite-related factors, particularly to the emergence of resistant populations.},
  keywords = {{O}nchocerca volvulus ; {O}nchocerciasis ; {I}vermectin ; {E}fficacy ; {I}nter-individual variability ; {R}esistance},
  booktitle = {},
  journal = {{A}cta {T}ropica},
  volume = {120},
  numero = {{S}pecial {I}ssue {S}uppl. 1},
  pages = {{S}91--{S}99},
  ISSN = {0001-706{X}},
  year = {2011},
  DOI = {10.1016/j.actatropica.2010.05.004},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054197},
}