@article{fdi:010054162,
  title = {{A}ctivity-guided isolation of antileishmanial compounds from {P}iper hispidum},
  author = {{R}uiz, {C}. and {H}addad, {M}ohamed and {A}lban, {J}. and {B}ourdy, {G}enevi{\`e}ve and {R}eategui, {R}. and {C}astillo, {D}. and {S}auvain, {M}ichel and {D}eharo, {E}ric and {E}stevez, {Y}annick and {A}revalo, {J}. and {R}ojas, {R}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he bioassay-guided purification of the ethanolic extract from the leaves of {P}iper hispidum led to the isolation of one new amide, {N}-2-(3',4',5'-trimethoxyphenyl)ethyl-2-hydroxybenzamide (1) as well as two known chalcones 2'-hydroxy-3',4',6'-trimethoxychalcone (2); 2',4'-dihydroxy-6'-methoxychalcone (cardamonin, 3) and one known flavanone, 5,7-dihydroxyflavanone ({P}inocembrin, 4). {T}heir structures were elucidated on the basis of spectroscopic data, including homo-and heteronuclear correlation {NMR} experiments ({COSY}, {HSQC} and {HMBC}) and comparison with data reported in the literature. {T}he isolated compounds were tested against {L}eishmania amazonensis axenic amastigotes. {T}he results showed that the known chalcone 2 exhibited the most potent antileishmanial activity with an {IC}50 of 0.8 mu {M} (amphotericin {B}: {IC}50 = 0.2 mu {M}) but was shown to exhibit mild cytotoxicity.},
  keywords = {{P}iper ; {A}mide ; {C}halcone ; {F}lavanone ; {L}eishmaniasis},
  booktitle = {},
  journal = {{P}hytochemistry {L}etters},
  volume = {4},
  numero = {3},
  pages = {363--366},
  ISSN = {1874-3900},
  year = {2011},
  DOI = {10.1016/j.phytol.2011.08.001},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054162},
}