@article{fdi:010054140,
  title = {{L}eishmania antimony resistance : what we know what we can learn from the field},
  author = {{A}it-{O}udhia, {K}. and {G}azanion, {E}lodie and {V}ergnes, {B}aptiste and {O}ury, {B}runo and {S}ereno, {D}enis},
  editor = {},
  language = {{ENG}},
  abstract = {{L}eishmania is the causative agent of various forms of leishmaniasis, a significant cause of morbidity and mortality. {T}he clinical manifestations of the disease range from self-healing cutaneous and mucocutaneous skin ulcers to a fatal visceral form named visceral leishmaniasis or kala-azar. {I}n the absence of any effective vaccine, the only means to treat and control leishmaniasis is affordable medication. {T}he treatment choice is essentially directed by economic considerations; therefore, for a large majority of countries, chemotherapy relies only on the use of cheaper antimonial compounds. {T}he emergence of antimonial therapy failure in {I}ndia linked to proven parasite resistance has stressed questions about selective factors as well as transmission risk of drug resistance. {U}nfortunately, in most parts of the world, the frequency of parasite antimony resistance linked to treatment failure is unknown because of a lack of information on {L}eishmania antimony susceptibility. {T}his information is crucial for addressing the risk of selection and transmission of drug-resistant parasites, particularly in areas where antimony is the only chemotherapeutic alternative. {H}owever, the poor knowledge about factors that favor selection of resistant parasites, the multiplicity of the agents that can play a role in the in vivo antileishmanial activity of antimony, and the lack of a standard protocol to diagnose and survey parasite resistance all contribute to insufficient monitoring of antimony resistance. {I}n this review, we discuss on the factors potentially involved in the selection of antimony resistance in the field and discuss on the methods available for its diagnosis.},
  keywords = {},
  booktitle = {},
  journal = {{P}arasitology {R}esearch},
  volume = {109},
  numero = {5},
  pages = {1225--1232},
  ISSN = {0932-0113},
  year = {2011},
  DOI = {10.1007/s00436-011-2555-5},
  URL = {https://www.documentation.ird.fr/hor/fdi:010054140},
}