%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Banuls, Anne-Laure
%A Bastien, P.
%A Pomares, C.
%A Arevalo, J.
%A Fisa, R.
%A Hide, Mallorie
%T Clinical pleiomorphism in human leishmaniases, with special mention of asymptomatic infection
%D 2011
%L fdi:010053857
%G ENG
%J Clinical Microbiology and Infection
%@ 1198-743X
%K Asymptomatic carriage ; clinical diversity ; host susceptibility ; immune response ; Leishmania ; parasite genetic diversity ; unusual clinical forms
%M ISI:000295086100002
%N 10
%P 1451-1461
%R 10.1111/j.1469-0691.2011.03640.x
%U https://www.documentation.ird.fr/hor/fdi:010053857
%> https://www.documentation.ird.fr/intranet/publi/2011/10/010053857.pdf
%V 17
%W Horizon (IRD)
%X This review gives an update of current knowledge on the clinical pleiomorphism of Leishmania, with a special emphasis on the case of asymptomatic carriage. The first part describes the numerous unusual expressions of the disease that occur besides the classic ( visceral, cutaneous, and mucocutaneous) forms of leishmaniases. The second part deals with progress in the understanding of disease outcome in humans, and the possible future approaches to improve our knowledge in the field. The third part highlights the role of the too often neglected asymptomatic carrier compartment. This group could be key to understanding infraspecific differences in virulence and pathogenicity of the parasite, as well as identifying the genetic determinants involved in the expression of the disease.
%$ 052