@article{fdi:010053789,
  title = {{A}n oxygen reduction chain in the hyperthermophilic anaerobe {T}hermotoga maritima highlights horizontal gene transfer between {T}hermococcales and {T}hermotogales},
  author = {{L}e {F}ourn, {C}. and {B}rasseur, {G}. and {B}rochier {A}rmanet, {C}. and {P}ieulle, {L}. and {B}rioukhanov, {A}. and {O}llivier, {B}ernard and {D}olla, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he hyperthermophile {T}hermotoga maritima, although strictly anaerobic, is able to grow in the presence of low amounts of {O}-2. {H}ere, we show that this bacterium consumes {O}-2 via a three-partner chain involving an {NADH} oxidoreductase ({NRO}), a rubredoxin ({R}d) and a flavo-diiron protein ({F}pr{A}) (locus tags: {TM}_0754, {TM}_0659 and {TM}_0755, respectively). {I}n vitro experiments showed that the {NADH}-dependent {O}-2 consumption rate was 881.9 (+/- 106.7) mol {O}-2 consumed min(-1) per mol of {F}pr{A} at 37 degrees {C} and that water was the main end-product of the reaction. {W}e propose that this {O}-2 reduction chain plays a central role in the {O}-2 tolerance of {T}. maritima. {P}hylogenetic analyses suggest that the genes coding for these three components were acquired by an ancestor of {T}hermotogales from an ancestor of {T}hermococcales via a single gene transfer. {T}his event likely also involved two {ROS} scavenging enzymes (neelaredoxin and rubrerythrin) that are encoded by genes clustered with those coding for {F}pr{A}, {NRO} and {R}d in the ancestor of {T}hermococcales. {S}uch genomic organization would have provided the ancestor of {T}hermotogales with a complete set of enzymes dedicated to {O}-2-toxicity defence. {B}eside {T}hermotogales and {T}hermococcales, horizontal gene transfers have played a major role in disseminating these enzymes within the hyperthermophilic anaerobic prokaryotic communities, allowing them to cope with fluctuating oxidative conditions that exist in situ.},
  keywords = {},
  booktitle = {},
  journal = {{E}nvironmental {M}icrobiology},
  volume = {13},
  numero = {8},
  pages = {2132--2145},
  ISSN = {1462-2912},
  year = {2011},
  DOI = {10.1111/j.1462-2920.2011.02439.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053789},
}