@article{fdi:010053769,
  title = {{F}irst evidence that parasite infecting apparent aparasitemic serological suspects in human {A}frican trypanosomiasis are {T}rypanosoma brucei gambiense and are similar to those found in patients},
  author = {{K}abor{\'e}, {J}. and {K}offi, {M}. and {B}ucheton, {B}runo and {M}ac{L}eod, {A}. and {D}uffy, {C}. and {I}lboudo, {H}. and {C}amara, {M}. and {D}e {M}eeûs, {T}hierry and {B}elem, {A}. {M}. {G}. and {J}amonneau, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{T}hanks to its sensitivity and its ease of use in the field, the card agglutination test for trypanosomiasis ({CATT}) is widely used for serological screening of {T}rypanosoma brucei gambiense human {A}frican trypanosomiasis ({HAT}). {P}ositive subjects are then examined by microscopy to confirm the disease. {H}owever, the {CATT} exhibits false-positive results raising the question of whether {CATT}-positive subjects who are not confirmed by microscopic detection of trypanosomes ({SERO}) are truly exposed to {T}.b. gambiense infection. {F}or this purpose, we applied microsatellite genotyping on {DNA} extracted from blood of both {HAT} confirmed patients and {SERO} subjects in {G}uinea and {C}ote d'{I}voire since microsatellite genotyping has proved useful for the study of {T}.b. gambiense genetic diversity. {P}roblems of amplification failures raise the question of the sensitivity of microsatellite markers when applied on biological samples especially from {SERO} subjects for who low blood parasitaemia are suspected. {N}evertheless, we have shown that the trypanosomes from {SERO} individuals that have been genotyped belong to {T}.b. gambiense group 1 and were identical to those found in {HAT} patients. {T}hese results constitute the first evidences that at least some {SERO} are indeed infected by {T}.b. gambiense group 1 and that they may constitute a human reservoir of parasite in {HAT} foci. {W}hether these individuals should undergo treatment remains an open question as long as their role in {HAT} transmission is unknown. {O}ur results strongly recommend the follow-up of such subjects to improve control strategies.},
  keywords = {{H}uman {A}frican trypanosomiasis ; {T}rypanosoma brucei gambiense ; {S}eropositive ; {C}ote d'{I}voire ; {G}uinea ; {H}uman reservoir ; {C}ontrol strategies},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {11},
  numero = {6},
  pages = {1250--1255},
  ISSN = {1567-1348},
  year = {2011},
  DOI = {10.1016/j.meegid.2011.04.014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053769},
}