%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Thomas, F.
%A Elguero, Eric
%A Brodeur, J.
%A Le Goff, J.
%A Missé, Dorothée
%T Herpes simplex virus type 2 and cancer : a medical geography approach
%D 2011
%L fdi:010053762
%G ENG
%J Infection Genetics and Evolution
%@ 1567-1348
%K Genital herpes ; Medical geography ; Prostate cancer ; Melanoma
%M ISI:000293804600011
%N 6
%P 1239-1242
%R 10.1016/j.meegid.2011.04.009
%U https://www.documentation.ird.fr/hor/fdi:010053762
%> https://www.documentation.ird.fr/intranet/publi/2011/09/010053762.pdf
%V 11
%W Horizon (IRD)
%X Herpes simplex virus type-2 (HSV-2) has been identified as a possible aetiological agent of cancer in humans, especially prostate cancer, but results remain controversial. Here, we have addressed this question using a medical geography approach based on the national incidence of various cancers and seroprevalence of HSV-2 in 64 countries worldwide. We corrected reports of cancer incidence for national gross domestic product (GDP) because living in a wealthy nation likely increases the probability of having a cancer detected. Data were also corrected for latitude and diet. Our analysis not only confirms that prostate cancer and HSV-2 seroprevalence are positively associated, but it also reveals the existence of a positive relationship between HSV-2 and melanoma incidence in both men and women. These results, though correlational, suggest that HSV-2 should continue to be investigated as a possible oncogenic pathogen of humans.
%$ 052