@article{fdi:010053710,
  title = {{R}eproductive strategies and population structure in {L}eishmania : substantial amount of sex in {L}eishmania {V}iannia guyanensis},
  author = {{R}ougeron, {V}irginie and {B}anuls, {A}nne-{L}aure and {C}arme, {B}. and {S}imon, {S}. and {C}ouppie, {P}. and {N}acher, {M}. and {H}ide, {M}alaurie and {D}e {M}eeûs, {T}hierry},
  editor = {},
  language = {{ENG}},
  abstract = {{L}eishmania species of the subgenus {V}iannia and especially {L}eishmania {V}iannia guyanensis are responsible for a large proportion of {N}ew {W}orld leishmaniasis cases. {S}ince a recent publication on {L}eishmania {V}iannia braziliensis, the debate on the mode of reproduction of {L}eishmania parasites has been reopened. {A} predominant endogamic reproductive mode (mating with relatives), together with strong {W}ahlund effects (sampling of strains from heterogeneous subpopulations), was indeed evidenced. {T}o determine whether this hypothesis can be generalized to other {L}eishmania {V}iannia species, we performed a population genetic study on 153 human strains of {L}. ({V}.) guyanensis from {F}rench {G}uiana based on 12 microsatellite loci. {T}he results revealed important homozygosity and very modest linkage disequilibrium, which is in agreement with a high level of sexual recombination and substantial endogamy. {T}hese results also revealed a significant isolation by distance with relatively small neighbourhoods and hence substantial viscosity of {L}eishmania populations in {F}rench {G}uiana. {T}hese results are of epidemiological relevance and suggest a major role for natural hosts and/or vectors in parasite strain diffusion across the country as compared to human hosts.},
  keywords = {clonality ; endogamy ; {L}eishmania {V}iannia guyanensis ; microsatellites ; population genetics ; substructuring},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {20},
  numero = {15},
  pages = {3116--3127},
  ISSN = {0962-1083},
  year = {2011},
  DOI = {10.1111/j.1365-294{X}.2011.05162.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053710},
}