@article{fdi:010053703,
  title = {{H}uman host determinants influencing the outcome of {T}rypanosoma brucei gambiense infections},
  author = {{B}ucheton, {B}runo and {M}ac{L}eod, {A}. and {J}amonneau, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince first identified, human {A}frican trypanosomiasis ({HAT}) or sleeping sickness has been described as invariably fatal. {I}ncreasing data however argue that infection by {T}rypanosoma brucei gambiense, the causative agent of {HAT}, results in a wide range of outcomes in its human host and importantly that a number of subjects in endemic areas are apparently able to control infection to low levels, undetectable by the classical parasitological tests used in the field. {T}hus, trypanotolerance seems to occur in humans as has already been described in cattle or in the rodent experimental models of infection. {T}his review focuses on the description of the diversity of outcomes resulting from {T}. b. gambiense in humans and on the host factors involved. {T}he consequences/impacts on {HAT} epidemiology resulting from this diversity are also discussed with regard to implementing sustainable {HAT} control strategies.},
  keywords = {asymptomatic carriers ; epidemiology ; genetic factors ; {H}uman {A}frican ; trypanosomiasis ; {T}rypanosoma brucei gambiense ; trypanotolerance},
  booktitle = {},
  journal = {{P}arasite {I}mmunology},
  volume = {33},
  numero = {8},
  pages = {438--447},
  ISSN = {0141-9838},
  year = {2011},
  DOI = {10.1111/j.1365-3024.2011.01287.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053703},
}