%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Barea, C.
%A Pabon, A.
%A Castillo, D.
%A Zimic, M.
%A Quiliano, M.
%A Galiano, S.
%A Perez-Silanes, S.
%A Monge, A.
%A Deharo, Eric
%A Aldana, I.
%T New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
%D 2011
%L fdi:010053699
%G ENG
%J Bioorganic and Medicinal Chemistry Letters
%@ 0960-894X
%K Quinoxaline ; N-Oxides ; Malaria ; Leishmaniasis
%M ISI:000292729900024
%N 15
%P 4498-4502
%R 10.1016/j.bmcl.2011.05.125
%U https://www.documentation.ird.fr/hor/fdi:010053699
%> https://www.documentation.ird.fr/intranet/publi/2011/08/010053699.pdf
%V 21
%W Horizon (IRD)
%X Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found.
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