@article{fdi:010053699,
  title = {{N}ew salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-{N}-oxide with antileishmanial and antimalarial activities},
  author = {{B}area, {C}. and {P}abon, {A}. and {C}astillo, {D}. and {Z}imic, {M}. and {Q}uiliano, {M}. and {G}aliano, {S}. and {P}erez-{S}ilanes, {S}. and {M}onge, {A}. and {D}eharo, {E}ric and {A}ldana, {I}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ontinuing with our efforts to identify new active compounds against malaria and leishmaniasis, 14 new 3-amino-1,4-di-{N}-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against {P}lasmodium falciparum {C}olombian {FCR}-3 strain and {L}eishmania amazonensis strain {MHOM}/{BR}/76/{LTB}-012{A}. {F}urther computational studies were carried out in order to analyze graphic {SAR} and {ADME} properties. {T}he results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. {I}n addition, interesting {ADME} properties were found.},
  keywords = {{Q}uinoxaline ; {N}-{O}xides ; {M}alaria ; {L}eishmaniasis},
  booktitle = {},
  journal = {{B}ioorganic and {M}edicinal {C}hemistry {L}etters},
  volume = {21},
  numero = {15},
  pages = {4498--4502},
  ISSN = {0960-894{X}},
  year = {2011},
  DOI = {10.1016/j.bmcl.2011.05.125},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053699},
}