Menemedengue V. auteur aut IRD Sahnouni K. auteur aut IRD Basco Leonardo auteur aut IRD Tahar Rachida auteur aut IRD text journalArticle eng text/pdf reformatted digital access Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes are reliable molecular markers for antifolate resistance. The P. falciparum ATPase 6 (pfatp6) gene has been proposed to be a potential marker for artemisinin resistance. In our previous clinical study, we showed that artesunate-sulfadoxine-pyrimethamine is highly effective against uncomplicated malaria in Yaounde, Cameroon. In the present study, dhfr, dhps, and pfatp6 mutations in P falciparum isolates obtained from children treated with artesunate-sulfadoxine-pyrimethamine were determined. All 61 isolates had wild-type Pfatp6 263, 623, and 769 alleles, and 11(18%) had a single E431K substitution. Three additional mutations, E643Q, E432K, and E641Q, were detected. The results did not indicate any warning signal of serious concern (i.e., no parasites were seen with quintuple dhfr-dhps, DHFR Ile164Leu, or pfatp6 mutations), as confirmed by the high clinical efficacy of artesunate-sulfadoxine-pyrimethamine. Further studies are required to identify a molecular marker that reliably predicts artemisinin resistance. specialized 052 85 1 22-25 2011 0002-9637 https://www.documentation.ird.fr/hor/fdi:010053687 10.4269/ajtmh.2011.10-0523 0002-9637 [F B010053687] https://www.documentation.ird.fr/hor/fdi:010053687 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers20-08/010053687.pdf IRD - Base Horizon / Pleins textes 2011-09-01 2020-09-17 fdi:010053687 fre