%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ozoh, G. A.
%A Murdoch, M. E.
%A Bissek, A. C.
%A Hagan, M.
%A Ogbuagu, K.
%A Shamad, M.
%A Braide, E. I.
%A Boussinesq, Michel
%A Noma, M. M.
%A Murdoch, I. E.
%A Seketeli, A.
%A Amazigo, U. V.
%T The African Programme for Onchocerciasis Control : impact on onchocercal skin disease
%D 2011
%L fdi:010053662
%G ENG
%J Tropical Medicine and International Health
%@ 1360-2276
%K onchocerciasis ; onchocercal skin disease ; African Programme for ; Onchocerciasis Control ; impact
%M ISI:000292290300015
%N 7
%P 875-883
%R 10.1111/j.1365-3156.2011.02783.x
%U https://www.documentation.ird.fr/hor/fdi:010053662
%> https://www.documentation.ird.fr/intranet/publi/2011/07/010053662.pdf
%V 16
%W Horizon (IRD)
%X OBJECTIVES To assess the long-term impact of the African Programme for Onchocerciasis Control on itching and onchocercal skin disease (OSD). METHODS Seven study sites in Cameroon, Sudan, Nigeria and Uganda participated. Two cross-sectional surveys were conducted of communities meso- and hyper-endemic for onchocerciasis before and after 5 or 6 years of community-directed treatment with ivermectin (CDTI). Individuals were asked about any general health symptoms including itching and underwent full cutaneous examinations. Onchocercal skin lesions were documented according to a standard classification. RESULTS Five thousand one hundred and ninety three people were examined in phase I and 5,180 people in phase II. The presence of onchocercal nodules was a strongly significant ( P < 0.001) risk factor for all forms of onchocercal skin disease: APOD (OR 1.66); CPOD (OR 2.84); LOD (OR 2.68); reactive skin lesions (OR 2.38) and depigmentation (OR 3.36). The effect of community-directed treatment with ivermectin was profound. At phase II, there were significant (P < 0 001) reductions in the odds of itching (OR 0.32), APOD (OR 0.28); CPOD (OR 0.34); reactive skin lesions (OR 0.33); depigmentation (OR 0.31) and nodules (OR 0.37). Reduction in the odds of LOD was also significant (OR 0.54, P < 0.03). CONCLUSIONS This first multi-country report of the long-term impact of CDTI reveals a substantial reduction in itching and OSD. APOC operations are having a major effect in improving skin health in poor rural populations in Africa.
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