@article{fdi:010053662,
  title = {{T}he {A}frican {P}rogramme for {O}nchocerciasis {C}ontrol : impact on onchocercal skin disease},
  author = {{O}zoh, {G}. {A}. and {M}urdoch, {M}. {E}. and {B}issek, {A}. {C}. and {H}agan, {M}. and {O}gbuagu, {K}. and {S}hamad, {M}. and {B}raide, {E}. {I}. and {B}oussinesq, {M}ichel and {N}oma, {M}. {M}. and {M}urdoch, {I}. {E}. and {S}eketeli, {A}. and {A}mazigo, {U}. {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{OBJECTIVES} {T}o assess the long-term impact of the {A}frican {P}rogramme for {O}nchocerciasis {C}ontrol on itching and onchocercal skin disease ({OSD}). {METHODS} {S}even study sites in {C}ameroon, {S}udan, {N}igeria and {U}ganda participated. {T}wo cross-sectional surveys were conducted of communities meso- and hyper-endemic for onchocerciasis before and after 5 or 6 years of community-directed treatment with ivermectin ({CDTI}). {I}ndividuals were asked about any general health symptoms including itching and underwent full cutaneous examinations. {O}nchocercal skin lesions were documented according to a standard classification. {RESULTS} {F}ive thousand one hundred and ninety three people were examined in phase {I} and 5,180 people in phase {II}. {T}he presence of onchocercal nodules was a strongly significant ( {P} < 0.001) risk factor for all forms of onchocercal skin disease: {APOD} ({OR} 1.66); {CPOD} ({OR} 2.84); {LOD} ({OR} 2.68); reactive skin lesions ({OR} 2.38) and depigmentation ({OR} 3.36). {T}he effect of community-directed treatment with ivermectin was profound. {A}t phase {II}, there were significant ({P} < 0 001) reductions in the odds of itching ({OR} 0.32), {APOD} ({OR} 0.28); {CPOD} ({OR} 0.34); reactive skin lesions ({OR} 0.33); depigmentation ({OR} 0.31) and nodules ({OR} 0.37). {R}eduction in the odds of {LOD} was also significant ({OR} 0.54, {P} < 0.03). {CONCLUSIONS} {T}his first multi-country report of the long-term impact of {CDTI} reveals a substantial reduction in itching and {OSD}. {APOC} operations are having a major effect in improving skin health in poor rural populations in {A}frica.},
  keywords = {onchocerciasis ; onchocercal skin disease ; {A}frican {P}rogramme for ; {O}nchocerciasis {C}ontrol ; impact},
  booktitle = {},
  journal = {{T}ropical {M}edicine and {I}nternational {H}ealth},
  volume = {16},
  numero = {7},
  pages = {875--883},
  ISSN = {1360-2276},
  year = {2011},
  DOI = {10.1111/j.1365-3156.2011.02783.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053662},
}