@article{fdi:010053656, title = {{E}bola and {M}arburg haemorrhagic fever viruses : major scientific advances, but a relatively minor public health threat for {A}frica}, author = {{L}eroy, {E}ric and {G}onzalez, {J}ean-{P}aul and {B}aize, {S}.}, editor = {}, language = {{ENG}}, abstract = {{E}bola and {M}arburg viruses are the only members of the {F}iloviridae family (order {M}ononegavirales), a group of viruses characterized by a linear, non-segmented, single-strand negative {RNA} genome. {T}hey are among the most virulent pathogens for humans and great apes, causing acute haemorrhagic fever and death within a matter of days. {S}ince their discovery 50 years ago, filoviruses have caused only a few outbreaks, with 2317 clinical cases and 1671 confirmed deaths, which is negligible compared with the devastation caused by malnutrition and other infectious diseases prevalent in {A}frica (malaria, cholera, {AIDS}, dengue, tuberculosis.). {Y}et considerable human and financial resourses have been devoted to research on these viruses during the past two decades, partly because of their potential use as bioweapons. {A}s a result, our understanding of the ecology, host interactions, and control of these viruses has improved considerably.}, keywords = {{E}bola ; immunity ; {M}arburg ; outbreak ; reservoir ; vaccine}, booktitle = {}, journal = {{C}linical {M}icrobiology and {I}nfection}, volume = {17}, numero = {7}, pages = {964--976}, ISSN = {1198-743{X}}, year = {2011}, DOI = {10.1111/j.1469-0691.2011.03535.x}, URL = {https://www.documentation.ird.fr/hor/fdi:010053656}, }