Charrel R. auteur aut IRD Coutard B. auteur aut IRD Baronti Cécile auteur aut IRD Canard B. auteur aut IRD Nougairede A. auteur aut IRD Frangeul A. auteur aut IRD Morin B. auteur aut IRD Jamal S. auteur aut IRD Schmidt C. L. auteur aut IRD Hilgenfeld R. auteur aut IRD Klempa B. auteur aut IRD de Lamballerie Xavier auteur aut IRD text journalArticle eng text/pdf born digital access The arenaviruses and hantaviruses are segmented genome RNA viruses that are hosted by rodents. Due to their association with rodents, they are globally widespread and can infect humans via direct or indirect routes of transmission, causing considerable human morbidity and mortality. Nevertheless, despite their obvious and emerging importance as pathogens, there are currently no effective antiviral drugs (except ribavirin which proved effective against Lassa virus) with which to treat humans infected by any of these viruses. The EU-funded VIZIER project (Comparative Structural Genomics of Viral Enzymes Involved in Replication) was instigated with an ultimate view of contributing to the development of antiviral therapies for RNA viruses, including the arenaviruses and bunyaviruses. This review highlights some of the major features of the arenaviruses and hantaviruses that have been investigated during recent years. After describing their classification and epidemiology, we review progress in understanding the genomics as well as the structure and function of replicative enzymes achieved under the VIZIER program and the development of new disease control strategies. specialized Hantavirus Arenavirus Zoonosis Antiviral therapy 052 90 2 102-114 2011 0166-3542 https://www.documentation.ird.fr/hor/fdi:010053591 10.1016/j.antiviral.2011.02.009 0166-3542 [F B010053591] https://www.documentation.ird.fr/hor/fdi:010053591 https://www.documentation.ird.fr/intranet/publi/2011/06/010053591.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2011-07-01 2017-08-23 fdi:010053591 fre