@article{fdi:010053591,
  title = {{A}renaviruses and hantaviruses : from epidemiology and genomics to antivirals},
  author = {{C}harrel, {R}. and {C}outard, {B}. and {B}aronti, {C}{\'e}cile and {C}anard, {B}. and {N}ougairede, {A}. and {F}rangeul, {A}. and {M}orin, {B}. and {J}amal, {S}. and {S}chmidt, {C}. {L}. and {H}ilgenfeld, {R}. and {K}lempa, {B}. and de {L}amballerie, {X}avier},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he arenaviruses and hantaviruses are segmented genome {RNA} viruses that are hosted by rodents. {D}ue to their association with rodents, they are globally widespread and can infect humans via direct or indirect routes of transmission, causing considerable human morbidity and mortality. {N}evertheless, despite their obvious and emerging importance as pathogens, there are currently no effective antiviral drugs (except ribavirin which proved effective against {L}assa virus) with which to treat humans infected by any of these viruses. {T}he {EU}-funded {VIZIER} project ({C}omparative {S}tructural {G}enomics of {V}iral {E}nzymes {I}nvolved in {R}eplication) was instigated with an ultimate view of contributing to the development of antiviral therapies for {RNA} viruses, including the arenaviruses and bunyaviruses. {T}his review highlights some of the major features of the arenaviruses and hantaviruses that have been investigated during recent years. {A}fter describing their classification and epidemiology, we review progress in understanding the genomics as well as the structure and function of replicative enzymes achieved under the {VIZIER} program and the development of new disease control strategies.},
  keywords = {{H}antavirus ; {A}renavirus ; {Z}oonosis ; {A}ntiviral therapy},
  booktitle = {},
  journal = {{A}ntiviral {R}esearch},
  volume = {90},
  numero = {2},
  pages = {102--114},
  ISSN = {0166-3542},
  year = {2011},
  DOI = {10.1016/j.antiviral.2011.02.009},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053591},
}