@article{fdi:010053537,
  title = {{P}leural mesothelioma in {N}ew {C}aledonia : associations with environmental risk factors},
  author = {{B}aumann, {F}. and {M}aurizot, {P}. and {M}angeas, {M}organ and {A}mbrosi, {J}. {P}. and {D}ouwes, {J}. and {R}obineau, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND}: {H}igh incidences of malignant mesothelioma ({MM}) have been observed in {N}ew {C}aledonia. {P}revious work has shown an association between {MM} and soil containing serpentinite. {OBJECTIVES}: {W}e studied the spatial and temporal variation of {MM} and its association with environmental factors. {METHODS}: {W}e investigated the 109 {MM} cases recorded in the {C}ancer {R}egistry of {N}ew {C}aledonia between 1984 and 2008 and performed spatial, temporal, and space-time cluster analyses. {W}e conducted an ecological analysis involving 100 tribes over a large area including those with the highest incidence rates. {A}ssociations with environmental factors were assessed using logistic and {P}oisson regression analyses. {RESULTS}: {T}he highest incidence was observed in the {H}ouailou area with a world age-standardized rate of 128.7 per 100,000 person-years [95% confidence interval ({CI}), 70.41-137.84]. {A} significant spatial cluster grouped 18 tribes (31 observed cases vs. 8 expected cases; p = 0.001), but no significant temporal clusters were identified. {T}he ecological analyses identified serpentinite on roads as the greatest environmental risk factor (odds ratio = 495.0; 95% {CI}, 46.2-4679.7; multivariate incidence rate ratio = 13.0; 95% {CI}, 10.2-16.6). {T}he risk increased with serpentinite surface, proximity to serpentinite quarries and distance to the peridotite massif. {T}he association with serpentines was stronger than with amphiboles. {L}iving on a slope and close to dense vegetation appeared protective. {T}he use of whitewash, previously suggested to be a risk factor, was not associated with {MM} incidence. {CONCLUSIONS}: {P}resence of serpentinite on roads is a major environmental risk factor for mesothelioma in {N}ew {C}aledonia.},
  keywords = {antigorite ; asbestos ; cluster analysis ; ecological study ; environment ; mesothelioma ; {N}ew {C}aledonia ; serpentinite},
  booktitle = {},
  journal = {{E}nvironmental {H}ealth {P}erspectives},
  volume = {119},
  numero = {5},
  pages = {695--700},
  ISSN = {0091-6765},
  year = {2011},
  DOI = {10.1289/ehp.1002862},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053537},
}