@article{fdi:010053486,
  title = {{R}evisiting long-term adherence to highly active antiretroviral therapy in {S}enegal using latent class analysis},
  author = {{B}astard, {M}. and {F}all, {M}. {B}. {K}. and {L}ani{\`e}ce, {I}. and {T}averne, {B}ernard and {D}esclaux, {A}lice and {E}cochard, {R}. and {S}ow, {P}. {S}. and {D}elaporte, {E}ric and {E}tard, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}dherence is one of the main predictors of antiretroviral treatment success. {A} governmental initiative was launched in 1998 for {HIV}-infected patients in {S}enegal to provide access to highly active antiretroviral therapy. {M}ethods: {B}etween {A}ugust 1998 and {A}pril 2002, 404 adult patients were enrolled. {A}dherence measurements, defined as pills taken/pills prescribed, were assessed between {N}ovember 1999 and {A}pril 2009 using a pill count along with a questionnaire for 330 patients. {P}redictors of adherence were explored through a random-intercept {T}obit model and a latent class analysis ({LCA}) was performed to identify adherence trajectories. {W}e also performed a survival analysis taking into account gender and latent adherence classes. {R}esults: {M}edian treatment duration was 91 months (interquartile range, 84-101). {O}n average, adherence declined by 7% every year, was 30% lower for patients taking indinavir, and 12% higher for those receiving cotrimoxazole prophylaxis. {B}ased on the predicted probability of having an adherence >= 95%, {LCA} revealed 3 adherence behaviors and a better adherence for women. {A} quarter of patients had a high adherence trajectory over time and half had an intermediate one. {M}ale gender and low adherence behavior over time were independently associated with a higher mortality rate. {C}onclusions: {T}his study shows that an overall good adherence can be obtained in the long term in {S}enegal. {LCA} suggests a better adherence for women and points out a large subsample of patients with intermediate level of adherence behavior who are at risk for developing resistance to antiretroviral drugs. {T}his study warrants further research into gender issues.},
  keywords = {antiretroviral therapy ; adherence ; latent class analysis ; mixed model ; women ; {S}enegal},
  booktitle = {},
  journal = {{J}aids-{J}ournal of {A}cquired {I}mmune {D}eficiency {S}yndromes},
  volume = {57},
  numero = {1},
  pages = {55--61},
  ISSN = {1525-4135},
  year = {2011},
  DOI = {10.1097/{QAI}.0b013e318211b43b},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053486},
}