@article{fdi:010053474,
  title = {{M}alaria associated symptoms in pregnant women followed-up in {B}enin},
  author = {{H}uynh, {B}ich-{T}ram and {F}ievet, {N}adine and {G}baguidi, {G}. and {B}orgella, {S}ophie and {M}evo, {B}.{G}. and {M}assougbodji, {A}. and {D}eloron, {P}hilippe and {C}ot, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}t is generally agreed that in high transmission areas, pregnant women have acquired a partial immunity to malaria and when infected they present few or no symptoms. {H}owever, longitudinal cohort studies investigating the clinical presentation of malaria infection in pregnant women in stable endemic areas are lacking, and the few studies exploring this issue are unconclusive. {M}ethods: {A} prospective cohort of women followed monthly during pregnancy was conducted in three rural dispensaries in {B}enin from {A}ugust 2008 to {S}eptember 2010. {T}he presence of symptoms suggestive of malaria infection in 982 women during antenatal visits ({ANV}), unscheduled visits and delivery were analysed. {A} multivariate logistic regression was used to determine the association between symptoms and a positive thick blood smear ({TBS}). {R}esults: {D}uring routine {ANV}s, headache was the only symptom associated with a higher risk of positive {TBS} (a{OR} = 1.9; p < 0.001). {O}n the occasion of unscheduled visits, fever (a{OR} = 5.2; p < 0.001), headache (a{OR} = 2.1; p = 0.004) and shivering (a{OR} = 3.1; p < 0.001) were significantly associated with a malaria infection and almost 90% of infected women presented at least one of these symptoms. {T}wo thirds of symptomatic malaria infections during unscheduled visits occurred in late pregnancy and long after the last intermittent preventive treatment dose ({IPT}p). {C}onclusion: {T}he majority of pregnant women were symptomless during routine visits when infected with malaria in an endemic stable area. {T}he only suggestive sign of malaria (fever) was associated with malaria only on the occasion of unscheduled visits. {T}he prevention of malaria in pregnancy could be improved by reassessing the design of {IPT}p, i.e. by determining an optimal number of doses and time of administration of anti-malarial drugs.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {10},
  numero = {},
  pages = {72},
  ISSN = {1475-2875},
  year = {2011},
  DOI = {10.1186/1475-2875-10-72},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053474},
}