@article{fdi:010053440,
  title = {{E}xceptional diversity, maintenance of polymorphism, and recent directional selection on the {APL}1 malaria resistance genes of {A}nopheles gambiae},
  author = {{R}ottschaefer, {S}. {M}. and {R}iehle, {M}. {M}. and {C}oulibaly, {B}. and {S}acko, {M}. and {N}iar{\'e}, {O}. and {M}orlais, {I}sabelle and {T}raor{\'e}, {S}. {F}. and {V}ernick, {K}. {D}. and {L}azzaro, {B}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he three-gene {APL}1 locus encodes essential components of the mosquito immune defense against malaria parasites. {APL}1 was originally identified because it lies within a mapped {QTL} conferring the vector mosquito {A}nopheles gambiae natural resistance to the human malaria parasite, {P}lasmodium falciparum, and {APL}1 genes have subsequently been shown to be involved in defense against several species of {P}lasmodium. {H}ere, we examine molecular population genetic variation at the {APL}1 gene cluster in spatially and temporally diverse {W}est {A}frican collections of {A}. gambiae. {T}he locus is extremely polymorphic, showing evidence of adaptive evolutionary maintenance of genetic variation. {W}e hypothesize that this variability aids in defense against genetically diverse pathogens, including {P}lasmodium. {V}ariation at {APL}1 is highly structured across geographic and temporal subpopulations. {I}n particular, diversity is exceptionally high during the rainy season, when malaria transmission rates are at their peak. {M}uch less allelic diversity is observed during the dry season when mosquito population sizes and malaria transmission rates are low. {APL}1 diversity is weakly stratified by the polymorphic 2{L}a chromosomal inversion but is very strongly subdivided between the {M} and {S} "molecular forms." {W}e find evidence that a recent selective sweep has occurred at the {APL}1 locus in {M} form mosquitoes only. {T}he independently reported observation of a similar {M}-form restricted sweep at the {T}ep1 locus, whose product physically interacts with {APL}1{C}, suggests that epistatic selection may act on these two loci causing them to sweep coordinately.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {B}iology},
  volume = {9},
  numero = {3},
  pages = {e1000600},
  ISSN = {1544-9173},
  year = {2011},
  DOI = {10.1371/journal.pbio.1000600},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053440},
}