%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Boulanger, Denis
%A Sarr, J. B.
%A Fillol, Florie
%A Sokhna, Cheikh
%A Cissé, B.
%A Schacht, A. M.
%A Trape, Jean-François
%A Riveau, G.
%A Simondon, François
%A Greenwood, B.
%A Remoué, Franck
%T Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children
%D 2010
%L fdi:010053155
%G ENG
%J Malaria Journal
%@ 1475-2875
%M ISI:000287604500001
%P 363
%R 10.1186/1475-2875-9-363
%U https://www.documentation.ird.fr/hor/fdi:010053155
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-02/010053155.pdf
%V 9
%W Horizon (IRD)
%X Background: Intermittent preventive treatment in children (IPTc) is a promising strategy to control malaria morbidity. A significant concern is whether IPTc increases children's susceptibility to subsequent malaria infection by altering their anti-Plasmodium acquired immunity. Methods: To investigate this concern, IgG antibody (Ab) responses to Plasmodium falciparum schizont extract were measured in Senegalese children (6 months-5 years old) who had received three rounds of IPTc with artesunate + sulphadoxine-pyrimethamine (or placebo) at monthly intervals eight months earlier. Potential confounding factors, such as asexual malaria parasitaemia and nutritional status were also evaluated. Results: Firstly, a bivariate analysis showed that children who had received IPTc had lower anti-Plasmodium IgG Ab levels than the non-treated controls. When epidemiological parameters were incorporated into a multivariate regression, gender, nutritional status and haemoglobin concentration did not have any significant influence. In contrast, parasitaemia, past malaria morbidity and increasing age were strongly associated with a higher specific IgG response. Conclusions: The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses. Previous IPTc does not seem to interfere with this parasite-dependent acquired humoral response eight months after the last drug administration.
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