@article{fdi:010053155,
  title = {{I}mmunological consequences of intermittent preventive treatment against malaria in {S}enegalese preschool children},
  author = {{B}oulanger, {D}enis and {S}arr, {J}. {B}. and {F}illol, {F}lorie and {S}okhna, {C}heikh and {C}iss{\'e}, {B}. and {S}chacht, {A}. {M}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {R}iveau, {G}. and {S}imondon, {F}ran{\c{c}}ois and {G}reenwood, {B}. and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}ntermittent preventive treatment in children ({IPT}c) is a promising strategy to control malaria morbidity. {A} significant concern is whether {IPT}c increases children's susceptibility to subsequent malaria infection by altering their anti-{P}lasmodium acquired immunity. {M}ethods: {T}o investigate this concern, {I}g{G} antibody ({A}b) responses to {P}lasmodium falciparum schizont extract were measured in {S}enegalese children (6 months-5 years old) who had received three rounds of {IPT}c with artesunate + sulphadoxine-pyrimethamine (or placebo) at monthly intervals eight months earlier. {P}otential confounding factors, such as asexual malaria parasitaemia and nutritional status were also evaluated. {R}esults: {F}irstly, a bivariate analysis showed that children who had received {IPT}c had lower anti-{P}lasmodium {I}g{G} {A}b levels than the non-treated controls. {W}hen epidemiological parameters were incorporated into a multivariate regression, gender, nutritional status and haemoglobin concentration did not have any significant influence. {I}n contrast, parasitaemia, past malaria morbidity and increasing age were strongly associated with a higher specific {I}g{G} response. {C}onclusions: {T}he intensity of the contacts with {P}. falciparum seems to represent the main factor influencing anti-schizont {I}g{G} responses. {P}revious {IPT}c does not seem to interfere with this parasite-dependent acquired humoral response eight months after the last drug administration.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {9},
  numero = {},
  pages = {363},
  ISSN = {1475-2875},
  year = {2010},
  DOI = {10.1186/1475-2875-9-363},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053155},
}