@article{fdi:010053143,
  title = {{M}alaria infection and disease in an area with pyrethroid-resistant vectors in southern {B}enin},
  author = {{D}amien, {G}. {B}. and {D}j{\`e}nontin, {A}rmel and {R}ogier, {C}. and {C}orbel, {V}incent and {B}angana, {S}. {B}. and {C}handre, {F}abrice and {A}kogb{\'e}to, {M}. and {K}ind{\'e}-{G}azard, {D}. and {M}assougbodji, {A}. and {H}enry, {M}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}his study aimed to investigate baseline data on malaria before the evaluation of new vector control strategies in an area of pyrethroid-resistance of vectors. {T}he burden of malaria was estimated in terms of infection (prevalence and parasite density) and of clinical episodes. {M}ethods: {B}etween {D}ecember 2007 and {D}ecember 2008 in the health district of {O}uidah - {K}pomasse - {T}ori {B}ossito (southern {B}enin), a descriptive epidemiological survey of malaria was conducted. {F}rom 28 selected villages, seven were randomized from which a total of 440 children aged 0 to 5 years were randomly selected. {C}linical and parasitological information was obtained by active case detection of malaria episodes carried out during eight periods of six consecutive days scheduled at six weekly intervals and by cross-sectional surveys of asymptomatic infection. {E}ntomological information was also collected. {T}he ownership, the use and the correct use of long-lasting insecticide-treated nets ({LLIN}s) were checked over weekly-survey by unannounced visits at home in the late evening. {R}esults: {M}ean parasite density in asymptomatic children was 586 {P}. falciparum asexual forms per mu {L} of blood (95% {CI} 504-680). {P}yrogenic parasite cut-off was estimated 2,000 {P}. falciparum asexual blood forms per mu {L}. {T}he clinical incidence of malaria was 1.5 episodes per child per year (95% {CI} 1.2-1.9). {P}arasitological and clinical variables did not vary with season. {A}nopheles gambiae s. l. was the principal vector closely followed by {A}nopheles funestus. {E}ntomological inoculation rate was 5.3 (95% {CI} 1.1-25.9) infective bites per human per year. {F}requency of the {L}1014{F} kdr ({W}est) allele was around 50%. {A}nnual prevalence rate of {P}lasmodium falciparum asymptomatic infection was 21.8% (95% {CI} 19.1-24.4) and increased according to age. {M}ean rates of ownership and use of {LLIN}s were 92% and 70% respectively. {T}he only correct use of {LLIN}s (63%) conferred 26% individual protection against only infection ({OR} = 0.74 (95% {IC} 0.62-0.87), p = 0.005). {C}onclusion: {T}he health district of {O}uidah-{K}pomasse-{T}ori {B}ossito is a mesoendemic area with a moderate level of pyrethroid-resistance of vectors. {T}he used {LLIN}s rate was high and only the correct use of {LLIN}s was found to reduce malaria infection without influencing malaria morbidity.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {9},
  numero = {},
  pages = {380},
  ISSN = {1475-2875},
  year = {2010},
  DOI = {10.1186/1475-2875-9-380},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053143},
}