da Silva A. J. M. auteur aut IRD Netto C. D. auteur aut IRD Pacienza-Lima W. auteur aut IRD Torres-Santos E. C. auteur aut IRD Rossi-Bergmann B. auteur aut IRD Maurel Séverine auteur aut IRD Valentin A. auteur aut IRD Costa P. R. R. auteur aut IRD text journalArticle eng text/pdf born digital access Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA). specialized antineoplasic antiparasitic pterocarpans naphtoquinones oxa-Heck reaction antimalarial leishmanicide 052 020 20 1 176-U222 2009 0103-5053 https://www.documentation.ird.fr/hor/fdi:010053051 0103-5053 [F B010053051] https://www.documentation.ird.fr/hor/fdi:010053051 https://www.documentation.ird.fr/intranet/publi/2009/compl3/010053051.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2011-03-23 2017-08-23 fdi:010053051 fre