%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A da Silva, A. J. M.
%A Netto, C. D.
%A Pacienza-Lima, W.
%A Torres-Santos, E. C.
%A Rossi-Bergmann, B.
%A Maurel, Séverine
%A Valentin, A.
%A Costa, P. R. R.
%T Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives
%D 2009
%L fdi:010053051
%G ENG
%J Journal of the Brazilian Chemical Society
%@ 0103-5053
%K antineoplasic ; antiparasitic ; pterocarpans ; naphtoquinones ; oxa-Heck ; reaction ; antimalarial ; leishmanicide
%M ISI:000262752400026
%N 1
%P 176-U222
%U https://www.documentation.ird.fr/hor/fdi:010053051
%> https://www.documentation.ird.fr/intranet/publi/2009/compl3/010053051.pdf
%V 20
%W Horizon (IRD)
%X Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA).
%$ 052 ; 020