Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives da Silva, A. J. M. Netto, C. D. Pacienza-Lima, W. Torres-Santos, E. C. Rossi-Bergmann, B. /Maurel, Séverine Valentin, A. Costa, P. R. R. antineoplasic antiparasitic pterocarpans naphtoquinones oxa-Heck reaction antimalarial leishmanicide Pterocarpanquinones 8a-c, previously synthesized in our laboratory, and an homologous series of derivatives, compounds 9a-c prepared in this work, were evaluated on breast cancer cells (MCF-7) and on the parasites Leishmania amazonensis and Plasmodium falciparum, in culture. Compounds 8a-c were more potent than 9a-c on tumor cells and Leishmania amazonensis. On the other hand, 9a-c showed to be more active on Plasmodium falciparum. All the compounds studied were bioselective, presenting negligible cytotoxicity against fresh murine lymphocytes and human lymphocytes activated by the mitogen phytohemaglutinin (PHA). 2009 text https://www.documentation.ird.fr/hor/fdi:010053051 fdi:010053051 da Silva A. J. M., Netto C. D., Pacienza-Lima W., Torres-Santos E. C., Rossi-Bergmann B., Maurel Séverine, Valentin A., Costa P. R. R.. Antitumoral, antileishmanial and antimalarial activity of pentacyclic 1,4-naphthoquinone derivatives. 2009, 20 (1), 176-U222 EN