@article{fdi:010053043,
  title = {{S}chistosoma haematobium infection affects {P}lasmodium falciparum-specific {I}g{G} responses associated with protection against malaria},
  author = {{C}ourtin, {D}avid and {S}id {A}hmed, {A}. and {M}ilet, {J}acqueline and {S}oulard, {V}al{\'e}rie and {G}aye, {O}. and {M}igot {N}abias, {F}lorence and {S}auerwein, {R}. and {G}arcia, {A}ndr{\'e} and {L}uty, {A}. {J}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e have previously shown that antibody responses directed to {P}lasmodium falciparum merozoite surface protein ({MSP})-1, {MSP}-2 and glutamate-rich protein ({GLURP}) are associated with anti-malarial protection in residents of the {N}iakhar area of {S}enegal. {I}n the same area, urinary schistosomiasis is frequent and we therefore assessed the possible influence of {S}chistosoma haematobium infection on these protective anti-malarial {I}g{G} responses. {A}fter adjustment for confounders, we found that the levels of {I}g{G}1 directed to {MSP}1 and {GLURP} were significantly lower in helminth carriers. {T}he higher circulating levels of interleukin ({IL})-10 present in the plasma of co-infected individuals were associated with decreased anti-plasmodial {I}g{G} responses, particularly of those directed to {MSP}-2. {O}ur data thus reveal a modulation of {P}. falciparum-specific immune responses in the presence of a trematode helminth infection, potentially increasing infected individuals' risk of plasmodial infection or disease.},
  keywords = {{I}g{G} ; malaria ; {P}lasmodium falciparum ; {S}histosoma haematobium ; shistosomiasis},
  booktitle = {},
  journal = {{P}arasite {I}mmunology},
  volume = {33},
  numero = {2},
  pages = {124--131},
  ISSN = {0141-9838},
  year = {2011},
  DOI = {10.1111/j.1365-3024.2010.01267.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053043},
}