@article{fdi:010053028,
  title = {{T}emporal transcriptomic response during arsenic stress in {H}erminiimonas arsenicoxydans},
  author = {{C}leiss {A}rnold, {J}. and {K}oechler, {S}. and {P}roux, {C}. and {F}ardeau, {M}arie-{L}aure and {D}illies, {M}.{A}. and {C}oppee, {J}.{Y}. and {A}rs{\`e}ne {P}loetze, {F}. and {B}ertin, {P}.{N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}rsenic is present in numerous ecosystems and microorganisms have developed various mechanisms to live in such hostile environments. {H}erminiimonas arsenicoxydans, a bacterium isolated from arsenic contaminated sludge, has acquired remarkable capabilities to cope with arsenic. {I}n particular our previous studies have suggested the existence of a temporal induction of arsenite oxidase, a key enzyme in arsenic metabolism, in the presence of {A}s({III}). {R}esults: {M}icroarrays were designed to compare gene transcription profiles under a temporal {A}s({III}) exposure. {T}ranscriptome kinetic analysis demonstrated the existence of two phases in arsenic response. {T}he expression of approximatively 14% of the whole genome was significantly affected by an {A}s({III}) early stress and 4% by an {A}s({III}) late exposure. {T}he early response was characterized by arsenic resistance, oxidative stress, chaperone synthesis and sulfur metabolism. {T}he late response was characterized by arsenic metabolism and associated mechanisms such as phosphate transport and motility. {T}he major metabolic changes were confirmed by chemical, transcriptional, physiological and biochemical experiments. {T}hese early and late responses were defined as general stress response and specific response to {A}s({III}), respectively. {C}onclusion: {G}ene expression patterns suggest that the exposure to {A}s({III}) induces an acute response to rapidly minimize the immediate effects of {A}s({III}). {U}pon a longer arsenic exposure, a broad metabolic response was induced. {T}hese data allowed to propose for the first time a kinetic model of the {A}s({III}) response in bacteria.},
  keywords = {},
  booktitle = {},
  journal = {{B}mc {G}enomics},
  volume = {11},
  numero = {},
  pages = {709},
  ISSN = {1471-2164},
  year = {2010},
  DOI = {10.1186/1471-2164-11-709},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053028},
}