@article{fdi:010053014,
  title = {{R}evisiting the immune trypanolysis test to optimise epidemiological surveillance and control of sleeping sickness in {W}est {A}frica},
  author = {{J}amonneau, {V}incent and {B}ucheton, {B}runo and {K}abor{\'e}, {J}. and {I}lboudo, {H}amidou and {C}amara, {O}. and {C}ourtin, {F}abrice and {S}olano, {P}hilippe and {K}aba, {D}. and {K}ambire, {R}. and {L}ingue, {K}. and {C}amara, {M}. and {B}aelmans, {R}. and {L}ejon, {V}. and {B}uscher, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {B}ecause of its high sensitivity and its ease of use in the field, the card agglutination test for trypanosomiasis ({CATT}) is widely used for mass screening of sleeping sickness. {H}owever, the {CATT} exhibits false-positive results (i) raising the question of whether {CATT}-positive subjects who are negative in parasitology are truly exposed to infection and (ii) making it difficult to evaluate whether {T}rypanosoma brucei ({T}.b.) gambiense is still circulating in areas of low endemicity. {T}he objective of this study was to assess the value of the immune trypanolysis test ({TL}) in characterising the {HAT} status of {CATT}-positive subjects and to monitor {HAT} elimination in {W}est {A}frica. {M}ethodology/{P}rincipal {F}indings: {TL} was performed on plasma collected from {CATT}-positive persons identified within medical surveys in several {W}est {A}frican {HAT} foci in {G}uinea, {C}ote d'{I}voire and {B}urkina {F}aso with diverse epidemiological statuses (active, latent, or historical). {A}ll {HAT} cases were {TL}+. {A}ll subjects living in a nonendemic area were {TL}-. {CATT} prevalence was not correlated with {HAT} prevalence in the study areas, whereas a significant correlation was found using {TL}. {C}onclusion and {S}ignificance: {TL} appears to be a marker for contact with {T}.b. gambiense. {TL} can be a tool (i) at an individual level to identify nonparasitologically confirmed {CATT}-positive subjects as well as those who had contact with {T}.b. gambiense and should be followed up, (ii) at a population level to identify priority areas for intervention, and (iii) in the context of {HAT} elimination to identify areas free of {HAT}.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {N}eglected {T}ropical {D}iseases},
  volume = {4},
  numero = {12},
  pages = {e917},
  ISSN = {1935-2727},
  year = {2010},
  DOI = {10.1371/journal.pntd.0000917},
  URL = {https://www.documentation.ird.fr/hor/fdi:010053014},
}