Dramé Papa Maktar auteur aut IRD Poinsignon Anne auteur aut IRD Besnard P. auteur aut IRD Cornélie Sylvie auteur aut IRD Le Mire J. auteur aut IRD Toto J. C. auteur aut IRD Foumane V. auteur aut IRD Dos-Santos M. A. auteur aut IRD Sembène M. auteur aut IRD Fortes F. auteur aut IRD Simondon François auteur aut IRD Carnevale Pierre auteur aut IRD Remoué Franck auteur aut IRD text journalArticle eng text/pdf reformatted digital access To optimize malaria control, WHO has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. The gSG6-P1 peptide from gSG6 protein of Anopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species. It was shown that the quantification of human antibody (Ab) responses to Anopheles salivary proteins in general and especially to the gSG6-P1 peptide was a pertinent biomarker of human exposure to Anopheles. The present objective was to validate this indicator in the evaluation of the efficacy of Insecticide Treated Nets (ITNs). A longitudinal evaluation, including parasitological, entomological and immunological assessments, was conducted on children and adults from a malaria-endemic area before and after the introduction of ITNs. Significant decrease of anti-gSG6-P1 IgG response was observed just after the efficient ITNs use. Interestingly, specific IgG Ab level was especially pertinent to evaluate a short-time period of ITNs efficacy and at individual level. However, specific IgG rose back up within four months as correct ITN use waned. IgG responses to one salivary peptide could constitute a reliable biomarker for the evaluation of ITN efficacy, at short-and long-term use, and provide a valuable tool in malaria vector control based on a real measurement of human-vector contact. specialized ZONE TROPICALE 052 5 12 e15596 [9 ] 2010 1932-6203 https://www.documentation.ird.fr/hor/fdi:010052992 10.1371/journal.pone.0015596 1932-6203 [F B010052992] https://www.documentation.ird.fr/hor/fdi:010052992 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/divers17-08/010052992.pdf IRD - Base Horizon / Pleins textes 2011-02-04 2021-06-10 fdi:010052992 fre