@article{fdi:010052992,
  title = {{H}uman antibody responses to the {A}nopheles salivary g{SG}6-{P}1 peptide : a novel tool for evaluating the efficacy of {ITN}s in malaria vector control},
  author = {{D}ram{\'e}, {P}apa {M}aktar and {P}oinsignon, {A}nne and {B}esnard, {P}. and {C}orn{\'e}lie, {S}ylvie and {L}e {M}ire, {J}. and {T}oto, {J}. {C}. and {F}oumane, {V}. and {D}os-{S}antos, {M}. {A}. and {S}emb{\`e}ne, {M}. and {F}ortes, {F}. and {S}imondon, {F}ran{\c{c}}ois and {C}arnevale, {P}ierre and {R}emou{\'e}, {F}ranck},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o optimize malaria control, {WHO} has prioritised the need for new indicators to evaluate the efficacy of malaria vector control strategies. {T}he g{SG}6-{P}1 peptide from g{SG}6 protein of {A}nopheles gambiae salivary glands was previously designed as a specific salivary sequence of malaria vector species. {I}t was shown that the quantification of human antibody ({A}b) responses to {A}nopheles salivary proteins in general and especially to the g{SG}6-{P}1 peptide was a pertinent biomarker of human exposure to {A}nopheles. {T}he present objective was to validate this indicator in the evaluation of the efficacy of {I}nsecticide {T}reated {N}ets ({ITN}s). {A} longitudinal evaluation, including parasitological, entomological and immunological assessments, was conducted on children and adults from a malaria-endemic area before and after the introduction of {ITN}s. {S}ignificant decrease of anti-g{SG}6-{P}1 {I}g{G} response was observed just after the efficient {ITN}s use. {I}nterestingly, specific {I}g{G} {A}b level was especially pertinent to evaluate a short-time period of {ITN}s efficacy and at individual level. {H}owever, specific {I}g{G} rose back up within four months as correct {ITN} use waned. {I}g{G} responses to one salivary peptide could constitute a reliable biomarker for the evaluation of {ITN} efficacy, at short-and long-term use, and provide a valuable tool in malaria vector control based on a real measurement of human-vector contact.},
  keywords = {{ZONE} {TROPICALE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {5},
  numero = {12},
  pages = {e15596 [9 ]},
  ISSN = {1932-6203},
  year = {2010},
  DOI = {10.1371/journal.pone.0015596},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052992},
}