Ananworanich J. auteur aut IRD Apornpong T. auteur aut IRD Kosalaraksa P. auteur aut IRD Jaimulwong T. auteur aut IRD Hansudewechakul R. auteur aut IRD Pancharoen C. auteur aut IRD Bunupuradah T. auteur aut IRD Chandara M. auteur aut IRD Puthanakit T. auteur aut IRD Ngampiyasakul C. auteur aut IRD Wongsawat J. auteur aut IRD Kanjanavanit S. auteur aut IRD Luesomboon W. auteur aut IRD Klangsinsirikul P. auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Kerr S. J. auteur aut IRD Ubolyam S. auteur aut IRD Mengthaisong T. auteur aut IRD Gelman R. S. auteur aut IRD Pattanapanyasat K. auteur aut IRD Saphonn V. auteur aut IRD Ruxrungtham K. auteur aut IRD Shearer W. T. auteur aut IRD text journalArticle eng text/pdf born digital access Background: There are limited data on the immune profiles of HIV-positive children compared with healthy controls, and no such data for Asian children. Objectives: To immunophenotype HIV-positive Asian children, including long-term nonprogressors (LTNPs), compared with age-matched healthy controls. Methods: We used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, HIV-positive children with 15% to 24% CD4(+) T cells and no AIDS-related illnesses and 142 healthy children (controls). Data were compared among age categories. Profiles from LTNPs (n = 50), defined as children >= 8 years old with CD4(+) T-cell counts >= 350 cells/mm(3), were compared with data from age-matched non-LTNPs (n = 17) and controls (n = 53). Results: Compared with controls, HIV-positive children had lower values (cell count per mm(3) and percent distribution) for T-H cells and higher values for cytotoxic T cells, with reductions in populations of naive T-H and cytotoxic T cells, B cells, and natural killer (NK) cells. HIV-positive children had high values for activated T-H and cytotoxic T cells. Compared with non-LTNPs, LTNPs had higher values of T-H and cytotoxic T cells, naive and memory T-cell subsets, and B and NK cells. Surprisingly, counts of activated T-H and cytotoxic T cells were also higher among LTNPs. LNTPs were more frequently male. Conclusion: Untreated, HIV-infected Asian children have immune profiles that differ from those of controls, characterized by low values for T-H cells, naive T cells, B cells, and NK cells but high values for cytotoxic, activated T-H, and cytotoxic T cells. The higher values for activated T cells observed in LTNPs require confirmation in longitudinal studies. (J Allergy Clin Immunol 2010;126:1294-301.) specialized HIV children lymphocyte monocyte phenotyping long-term nonprogressors antiretroviral therapy Asia disease progression pediatric AIDS 050 126 6 1294-U352 2010 0091-6749 https://www.documentation.ird.fr/hor/fdi:010052972 10.1016/j.jaci.2010.09.038 0091-6749 [F B010052972] https://www.documentation.ird.fr/hor/fdi:010052972 https://www.documentation.ird.fr/intranet/publi/2011/01/010052972.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2011-02-04 2017-08-23 fdi:010052972 fre