%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Ananworanich, J.
%A Apornpong, T.
%A Kosalaraksa, P.
%A Jaimulwong, T.
%A Hansudewechakul, R.
%A Pancharoen, C.
%A Bunupuradah, T.
%A Chandara, M.
%A Puthanakit, T.
%A Ngampiyasakul, C.
%A Wongsawat, J.
%A Kanjanavanit, S.
%A Luesomboon, W.
%A Klangsinsirikul, P.
%A Ngo-Giang-Huong, Nicole
%A Kerr, S. J.
%A Ubolyam, S.
%A Mengthaisong, T.
%A Gelman, R. S.
%A Pattanapanyasat, K.
%A Saphonn, V.
%A Ruxrungtham, K.
%A Shearer, W. T.
%T Characteristics of lymphocyte subsets in HIV-infected, long-term nonprogressor, and healthy Asian children through 12 years of age
%D 2010
%L fdi:010052972
%G ENG
%J Journal of Allergy and Clinical Immunology
%@ 0091-6749
%K HIV ; children ; lymphocyte ; monocyte ; phenotyping ; long-term ; nonprogressors ; antiretroviral therapy ; Asia ; disease progression ; pediatric AIDS
%M ISI:000284947800030
%N 6
%P 1294-U352
%R 10.1016/j.jaci.2010.09.038
%U https://www.documentation.ird.fr/hor/fdi:010052972
%> https://www.documentation.ird.fr/intranet/publi/2011/01/010052972.pdf
%V 126
%W Horizon (IRD)
%X Background: There are limited data on the immune profiles of HIV-positive children compared with healthy controls, and no such data for Asian children. Objectives: To immunophenotype HIV-positive Asian children, including long-term nonprogressors (LTNPs), compared with age-matched healthy controls. Methods: We used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, HIV-positive children with 15% to 24% CD4(+) T cells and no AIDS-related illnesses and 142 healthy children (controls). Data were compared among age categories. Profiles from LTNPs (n = 50), defined as children >= 8 years old with CD4(+) T-cell counts >= 350 cells/mm(3), were compared with data from age-matched non-LTNPs (n = 17) and controls (n = 53). Results: Compared with controls, HIV-positive children had lower values (cell count per mm(3) and percent distribution) for T-H cells and higher values for cytotoxic T cells, with reductions in populations of naive T-H and cytotoxic T cells, B cells, and natural killer (NK) cells. HIV-positive children had high values for activated T-H and cytotoxic T cells. Compared with non-LTNPs, LTNPs had higher values of T-H and cytotoxic T cells, naive and memory T-cell subsets, and B and NK cells. Surprisingly, counts of activated T-H and cytotoxic T cells were also higher among LTNPs. LNTPs were more frequently male. Conclusion: Untreated, HIV-infected Asian children have immune profiles that differ from those of controls, characterized by low values for T-H cells, naive T cells, B cells, and NK cells but high values for cytotoxic, activated T-H, and cytotoxic T cells. The higher values for activated T cells observed in LTNPs require confirmation in longitudinal studies. (J Allergy Clin Immunol 2010;126:1294-301.)
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