@article{fdi:010052972,
  title = {{C}haracteristics of lymphocyte subsets in {HIV}-infected, long-term nonprogressor, and healthy {A}sian children through 12 years of age},
  author = {{A}nanworanich, {J}. and {A}pornpong, {T}. and {K}osalaraksa, {P}. and {J}aimulwong, {T}. and {H}ansudewechakul, {R}. and {P}ancharoen, {C}. and {B}unupuradah, {T}. and {C}handara, {M}. and {P}uthanakit, {T}. and {N}gampiyasakul, {C}. and {W}ongsawat, {J}. and {K}anjanavanit, {S}. and {L}uesomboon, {W}. and {K}langsinsirikul, {P}. and {N}go-{G}iang-{H}uong, {N}icole and {K}err, {S}. {J}. and {U}bolyam, {S}. and {M}engthaisong, {T}. and {G}elman, {R}. {S}. and {P}attanapanyasat, {K}. and {S}aphonn, {V}. and {R}uxrungtham, {K}. and {S}hearer, {W}. {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {T}here are limited data on the immune profiles of {HIV}-positive children compared with healthy controls, and no such data for {A}sian children. {O}bjectives: {T}o immunophenotype {HIV}-positive {A}sian children, including long-term nonprogressors ({LTNP}s), compared with age-matched healthy controls. {M}ethods: {W}e used flow cytometry to analyze 13 lymphocyte and monocyte subsets from 222 untreated, {HIV}-positive children with 15% to 24% {CD}4(+) {T} cells and no {AIDS}-related illnesses and 142 healthy children (controls). {D}ata were compared among age categories. {P}rofiles from {LTNP}s (n = 50), defined as children >= 8 years old with {CD}4(+) {T}-cell counts >= 350 cells/mm(3), were compared with data from age-matched non-{LTNP}s (n = 17) and controls (n = 53). {R}esults: {C}ompared with controls, {HIV}-positive children had lower values (cell count per mm(3) and percent distribution) for {T}-{H} cells and higher values for cytotoxic {T} cells, with reductions in populations of naive {T}-{H} and cytotoxic {T} cells, {B} cells, and natural killer ({NK}) cells. {HIV}-positive children had high values for activated {T}-{H} and cytotoxic {T} cells. {C}ompared with non-{LTNP}s, {LTNP}s had higher values of {T}-{H} and cytotoxic {T} cells, naive and memory {T}-cell subsets, and {B} and {NK} cells. {S}urprisingly, counts of activated {T}-{H} and cytotoxic {T} cells were also higher among {LTNP}s. {LNTP}s were more frequently male. {C}onclusion: {U}ntreated, {HIV}-infected {A}sian children have immune profiles that differ from those of controls, characterized by low values for {T}-{H} cells, naive {T} cells, {B} cells, and {NK} cells but high values for cytotoxic, activated {T}-{H}, and cytotoxic {T} cells. {T}he higher values for activated {T} cells observed in {LTNP}s require confirmation in longitudinal studies. ({J} {A}llergy {C}lin {I}mmunol 2010;126:1294-301.)},
  keywords = {{HIV} ; children ; lymphocyte ; monocyte ; phenotyping ; long-term ; nonprogressors ; antiretroviral therapy ; {A}sia ; disease progression ; pediatric {AIDS}},
  booktitle = {},
  journal = {{J}ournal of {A}llergy and {C}linical {I}mmunology},
  volume = {126},
  numero = {6},
  pages = {1294--{U}352},
  ISSN = {0091-6749},
  year = {2010},
  DOI = {10.1016/j.jaci.2010.09.038},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052972},
}