@article{fdi:010052910,
  title = {{R}odent host cell/{L}assa virus interactions : evolution and expression of alpha-{D}ystroglycan, {LARGE}-1 and {LARGE}-2 genes, with special emphasis on the {M}astomys genus},
  author = {{T}ayeh, {A}. and {T}atard, {C}. and {K}ako-{O}uraga, {S}. and {D}uplantier, {J}ean-{M}arc and {D}obigny, {G}authier},
  editor = {},
  language = {{ENG}},
  abstract = {{A}renaviruses are usually rodent-borne viruses that constitute a major threat for human health. {A}mong them, {L}assa {F}ever {V}irus ({LFV}) occurs in {W}estern {A}frica where it infects hundreds of thousands of people annually. {A}ccording to the most recent surveys, {LFV} is hosted by one of the multimammate rats, {M}astomys natalensis, but has never been detected in its sibling and sometimes sympatric species {M}astomys erythroleucus. {T}his pattern suggests that intrinsic, i.e. genetic properties underlie such a drastic epidemiological difference ({M}. natalensis as a reservoir vs. {M}. erythroleucus as a non-reservoir species). {H}ere we investigate genomic differences between these two closely related rodent species by focusing on three genes that have recently been described as pivotal for {LFV}/human cell interactions: {D}ystroglycan (the {LFV} cellular receptor). {LARGE}-1 and {LARGE}-2 (two enzymes that are essential to {D}ystroglycan functioning). {F}or all three genes, sequence analyses showed that amino-acid chains undergo extremely strong purifying selective pressures, and indicated that no nucleotide (therefore no tertiary structure) change can be advocated to explain species-specific differences in {LFV}-cellular mediation. {N}evertheless, preliminary studies of kidney-specific expression profiles suggested that important species-specific differences exist between {M}astomys species. {T}aking into account current knowledge about {LFV}-human cell interactions, our results may point towards a possible role for {LARGE}-1 and {LARGE}-2 enzymes at the intracellular replication level of the virus, rather than at the {LFV}-host cell receptor binding step.},
  keywords = {{R}odent-borne disease ; {A}renavirus ; {H}ost/parasite interactions ; {G}enomics},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {10},
  numero = {8},
  pages = {1262--1270},
  ISSN = {1567-1348},
  year = {2010},
  DOI = {10.1016/j.meegid.2010.07.018},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052910},
}