@article{fdi:010052840,
  title = {{P}lasmodium falciparum parasites causing cerebral malaria share variant surface antigens, but are they specific ?},
  author = {{K}heliouen, {N}abila and {V}iwami, {F}irmine and {L}alya, {F}. and {T}uikue {N}dam, {N}icaise and {E}boumou {M}oukoko, {E}. {C}. and {R}ogier, {C}. and {D}eloron, {P}hilippe and {A}ubouy, {A}gn{\`e}s},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {V}ariant surface antigens ({VSA}) expressed on the surface of {P}lasmodium falciparum-infected red blood cells constitute a key for parasite sequestration and immune evasion. {I}n distinct malaria pathologies, such as placental malaria, specific antibody response against {VSA} provides protection. {T}his study investigated the antibody response specifically directed against {VSA} expressed by parasites isolated from individuals presenting a given type of clinical presentation. {M}ethods: {P}lasma and isolates were obtained from four groups of {B}eninese subjects: healthy adults, patients presenting uncomplicated malaria ({UM}), cerebral malaria ({CM}), or pregnancy-associated malaria ({PAM}). {T}he reactivity of plasma samples from each clinical group was measured by flow cytometry against parasites isolated from individuals from each clinical group. {R}esults: {A}ntibody responses against {VSA}({UM}) were predominant in {CM}, {UM} and {HA} plasmas. {W}hen analysed according to age in all plasma groups, anti-{VSA}({CM}) and -{VSA}({UM}) antibody levels were similar until six years of age. {I}n older groups (6-18 and > 19 years of age), {VSA}({UM}) antibody levels were higher than {VSA}({CM}) antibody levels ({P} = .01, {P} = .0008, respectively). {M}ean {MFI} values, measured in all plasmas groups except the {PAM} plasmas, remained low for anti-{VSA}({PAM}) antibodies and did not vary with age. {O}ne month after infection the level of anti-{VSA} antibodies able to recognize heterologous {VSA}({CM}) variants was increased in {CM} patients. {I}n {UM} patients, antibody levels directed against heterologous {VSA}({UM}) were similar, both during the infection and one month later. {C}onclusions: {I}n conclusion, this study suggests the existence of serologically distinct {VSA}({CM}) and {VSA}({UM}). {CM} isolates were shown to share common epitopes. {S}pecific antibody response to {VSA}({UM}) was predominant, suggesting a relative low diversity of {VSA}({UM}) in the study area.},
  keywords = {},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {9},
  numero = {},
  pages = {220},
  ISSN = {1475-2875},
  year = {2010},
  DOI = {10.1186/1475-2875-9-220},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052840},
}