Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei De Marino, S. Sepe, V. D'Auria, M. V. Bifulco, G. Renga, B. /Petek, Sylvain Fiorucci, S. Zampella, A. Malaitasterol A, an unprecedented bis-secosterol, was isolated from a Solomon collection of Theonella swinhoei. The structure was elucidated on the basis of a combination of comprehensive 1D and 2D NMR analysis, high-resolution mass spectrometry and DFT C-13 chemical shift calculations. The biological characterization of malaitasterol A provided evidence that this compound is a potent agonist of pregnane-X-receptor and its putative binding mode to PXR has been obtained through docking calculations. 2011 text https://www.documentation.ird.fr/hor/fdi:010052514 fdi:010052514 De Marino S., Sepe V., D'Auria M. V., Bifulco G., Renga B., Petek Sylvain, Fiorucci S., Zampella A.. Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei. 2011, 9 (13), 4856-4862 EN