@article{fdi:010052478,
  title = {{I}nfluence of {CYP}2{B}6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in {HIV}-infected {T}hai women},
  author = {{C}hantarangsu, {S}. and {C}ressey, {T}im and {M}ahasirimongkol, {S}. and {C}apparelli, {E}. and {T}awon, {Y}. and {N}go {G}iang {H}uong, {N}icole and {J}ourdain, {G}onzague and {L}allemant, {M}arc and {C}hantratita, {W}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o investigate the association of single nucleotide polymorphisms ({SNP}s) with nevirapine concentrations following intra-partum single-dose nevirapine. {P}lasma and {DNA} samples were obtained from 330 {HIV}-infected {T}hai women who received intra-partum single-dose nevirapine in the {PHPT}-2 clinical trial to prevent perinatal {HIV} transmission. {N}ine {SNP}s within {CYP}2{B}6, {CYP}3{A}4 and {ABCB}1 were genotyped by real-time {PCR}. {N}evirapine plasma concentrations were determined by {HPLC} and used in a population pharmacokinetic analysis. {H}igher nevirapine exposure was observed in women carrying the {CYP}2{B}6 516{G} > {T} polymorphism, but this did not reach statistical significance ({P} = 0.054). {T}he {TGATC} {CYP}2{B}6 haplotype (g.3003{T}, 516{G}, 785{A}, g.18492{T} and g.21563{C}) was associated with increased nevirapine clearance and lower exposure ({P} = 0.0029). {T}he median time for nevirapine concentrations to reach 10 ng/m{L} post-partum (nevirapine {IC}50 for {HIV}-1) was 14 days [interquartile range ({IQR}, 14-18)] for {TGATC} homozygotes, 16 days (14-20) for {TGATC} heterozygotes and 18 days (14-20) for non-{TGATC} homozygotes ({P} = 0.020). {T}he {CYP}2{B}6 516{G} > {T} impact on nevirapine concentrations was less pronounced after intra-partum single-dose nevirapine than reported under steady-state conditions, perhaps due to lack of enzyme auto-induction at the time of dosing. {A}lthough the {TGATC} {CYP}2{B}6 haplotype may shorten the persistence of nevirapine post-partum, its practical implications for the prevention of {HIV} transmission or selection of resistance mutations are likely limited.},
  keywords = {pharmacogenetics ; single nucleotide polymorphisms ; {SNP}s},
  booktitle = {},
  journal = {{J}ournal of {A}ntimicrobial {C}hemotherapy},
  volume = {64},
  numero = {6},
  pages = {1265--1273},
  ISSN = {0305-7453},
  year = {2009},
  DOI = {10.1093/jac/dkp351},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052478},
}