Samleerat T. auteur aut IRD Braibant M. auteur aut IRD Jourdain Gonzague auteur aut IRD Moreau A. auteur aut IRD Ngo-Giang-Huong Nicole auteur aut IRD Leechanachai P. auteur aut IRD Hemvuttiphan J. auteur aut IRD Hinjiranandana T. auteur aut IRD Changchit T. auteur aut IRD Warachit B. auteur aut IRD Suraseranivong V. auteur aut IRD Lallemant Marc auteur aut IRD Barin F. auteur aut IRD text journalArticle eng text/pdf born digital access We analyzed the characteristics of the envelope genes of human immunodeficiency virus type 1 in 17 mother-infant pairs infected with variants of the CRF01_ AE clade. A total of 353 sequences covering almost the entire glycoprotein (gp) 120 region were available for analysis. We found that, even if the virus population in the mother was complex, only viruses of a restricted subset were transmitted to her infant, independently of whether transmission occurred in utero or during the intrapartum period. We did not find that shorter gp120 regions or fewer potential N- glycosylation sites(PNGS) were characteristic of viruses transmitted from mother to infant. However, our data suggest that a limited number of PNGS that seem to be conserved in all variants in infants but are not uniformly present in variants in mothers may confer an advantage for transmission of the virus, thereby highlighting the potentially important role of the " glycan shield." This finding was particularly significant for the PNGS at positions N301 and N384. specialized 052 198 6 868-876 2008 0022-1899 https://www.documentation.ird.fr/hor/fdi:010052477 10.1086/591251 0022-1899 [F B010052477] https://www.documentation.ird.fr/hor/fdi:010052477 https://www.documentation.ird.fr/intranet/publi/depot/2011-09-08/010052477.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2008-10-06 2017-08-23 fdi:010052477 fre