@article{fdi:010052124,
  title = {{G}enetic polymorphism of the beta-tubulin gene of {O}nchocerca volvulus in ivermectin naive patients from {C}ameroon, and its relationship with fertility of the worms},
  author = {{B}ourguinat, {C}. and {P}ion, {S}{\'e}bastien and {K}amgno, {J}. and {G}ardon, {J}acques and {G}ardon {W}endel, {N}. and {D}uke, {B}.{O}.{L}. and {P}richard, {R}. {K}. and {B}oussinesq, {M}ichel},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bservations of low response of patients infected with {O}nchocerca volvulus to ivermectin suggest that the parasite may be tinder a selection process toward potential resistance. {T}o limit the extension of this phenomenon, it is crucial to characterize the genes of {O}. volvulus that are involved. {F}or this, {O}. volvulus adult worms collected before the introduction of ivermectin in an onchocerciasis endemic area of central {C}ameroon were genotyped for beta-tubulin. {T}o derive a baseline to investigate the selective pressure of ivermectin, we analysed (1) the frequency distribution of the beta-tubulin alleles, and (2) the relationship between the different beta-tubulin related genotypes and the fertility status of the female worms. {T}he frequency of allele b of the beta-tubulin gene seas very low, as it teas observed in {W}est {A}frica. {W}e observed a deficit of heterozygous female worms leading to {H}ardy {W}einberg disequilibrium, which might be explained by a shorter life-span of these worms compared to the homozygous worms. {U}nexpectedly, our results also show that the heterozygous female worms were much less fertile than the homozygotes: more than two thirds of the homozygotes were fertile, whereas only 37%, of the heterozygotes were fertile. {T}hese results will be further considered when analysing post-treatment data.},
  keywords = {{O}nchocerca volvulus ; beta tubulin ; genetic polymorphism ; fertility ; {C}ameroon ; {CAMEROUN}},
  booktitle = {},
  journal = {{P}arasitology},
  volume = {132},
  numero = {{P}art 2},
  pages = {255--262},
  ISSN = {0031-1820},
  year = {2006},
  DOI = {10.1017/{S}0031182005008899},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052124},
}