@article{fdi:010052121,
  title = {{HIV} type 1 pol gene diversity and antiretroviral drug resistance mutations in the {D}emocratic {R}epublic of {C}ongo ({DRC})},
  author = {{V}idal, {N}icole and {M}ulanga, {C}laire and {B}azepeo, {S}.{E}. and {M}wamba, {J}.{K}. and {T}shimpaka, {J}. and {K}ashi, {M}. and {M}ama, {N}. and {V}alea, {D}. and {D}elaporte, {E}ric and {L}epira, {F}. and {P}eeters, {M}artine},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o study recombination and the natural polymorphism in pol of {HIV}-1 strains in the {D}emocratic {R}epublic of {C}ongo ({DRC}) we sequenced the protease and {RT} genes for 70 {HIV}-1 strains previously characterized in the env {V}3-{V}5 region from a sentinel surveillance study in 2002. {F}or 41 of the 70 (58.6%) strains, the same subtype/{CRF} designations were observed in pol and env. {T}wenty-three (32.9%) of 70 pol sequences were complex recombinants involving two to five subtypes as well as fragments that could not be classified into any of the known subtypes. {A}ll subtypes were involved in recombination events. {U}nclassified ({U}) and env subtype {H} strains were very likely to be recombinant strains. {O}verall, many minor mutations were identified in the protease sequences. {A}lthough at the time of our study {ARV} use was not yet widespread in {DRC}, three strains were identified with one major mutation associated with drug resistance: {L}90{M} and {M}46{L} in protease and {K}103{N} in {RT}.},
  keywords = {{CONGO}},
  booktitle = {},
  journal = {{A}ids {R}esearch and {H}uman {R}etroviruses},
  volume = {22},
  numero = {2},
  pages = {202--206},
  year = {2006},
  DOI = {10.1089/aid.2006.22.202},
  URL = {https://www.documentation.ird.fr/hor/fdi:010052121},
}