@article{fdi:010051887,
  title = {{G}enotypic drug resistance interpretation algorithms display high levels of discordance when applied to non-{B} strains from {HIV}-1 naive and treated patients},
  author = {{V}ergne, {L}aurence and {S}noeck, {J}. and {A}ghokeng {F}obang, {A}velin and {M}aes, {B}. and {V}alea, {D}. and {D}elaporte, {E}ric and {V}andamme, {A}.{M}. and {P}eeters, {M}artine and {V}an {L}aethem, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{G}enotypic drug resistance interpretation algorithms have been developed on patients infected with {HIV}-1 subtype {B} to interpret complex patterns of mutations. {A}s non-{B} strains are characterised by the natural presence of several resistance-related mutations, we examined to what extent this might result in interalgorithm discordances in naive and treated patients. {W}e compared the prediction by three algorithms ({ANRS}, {S}tanford and {R}ega) of drug susceptibilities to diverse {HIV}-1 strains from 272 naive and 156 treated patients. {I}n naive patients, higher levels of interalgorithm discordance were observed for predictions of protease inhibitor (0.60-39%) than for predictions of reverse transcriptase inhibitor susceptibility (0-4%). {T}he main reason for discordant protease inhibitor interpretation was the presence of resistance mutations that were natural protease polymorphisms. {I}n contrast, in the treated patients, more interalgorithm discordances were observed for predictions of reverse transcriptase inhibitor (5-48%) than protease inhibitor susceptibilities (10-31%). {D}iscordances were related to disagreement between the intermediate and susceptible scores, the intermediate and resistant scores and the interpretations of complex mutation patterns, related to cross-resistance and antagonistic interactions.},
  keywords = {genotypic resistance ; {HIV} ; interalgorithm interpretation discordances ; non {B} subtypes},
  booktitle = {},
  journal = {{F}ems {I}mmunology and {M}edical {M}icrobiology},
  volume = {46},
  numero = {1},
  pages = {53--62},
  ISSN = {0928-8244},
  year = {2006},
  DOI = {10.1111/j.1574-695{X}.2005.00011.x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010051887},
}