@article{fdi:010051872,
  title = {{R}estriction of foamy viruses by {APOBEC} cytidine deaminases},
  author = {{D}elebecque, {F}. and {S}uspene, {R}. and {C}alattini, {S}. and {C}asartelli, {N}. and {S}aib, {A}. and {F}roment, {A}lain and {W}ain {H}obson, {S}. and {G}essain, {A}. and {V}artanian, {J}.{P}. and {S}chwartz, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}oamy viruses ({FV}s) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. {W}e have examined whether members of the apolipoprotein {B}-editing catalytic polypeptide-like subunit ({APOBEC}) family of antiviral cytidine deaminases restrict replication of simian {FV}. {W}e show that human {APOBEC}3{G} is a potent inhibitor of {FV} infectivity in cell culture experiments. {T}his antiviral activity is associated with cytidine editing of the viral genome. {B}oth molecular {FV} clones and primary uncloned viruses were susceptible to {APOBEC}3{G}, and viral infectivity was also inhibited by murine and simian {APOBEC}3{G} homologues, as well as by human {APOBEC}3{F}. {W}ild-type and bet-deleted viruses were similarly sensitive to this antiviral activity, suggesting that {B}et does not significantly counteract {APOBEC} proteins. {M}oreover, we did not detect {FV} sequences that may have been targeted by {APOBEC} in naturally infected macaques, but we observed a few {G}-to-{A} substitutions in humans that have been accidentally contaminated by simian {FV}. {I}n infected hosts, the persistence strategy employed by {FV} might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases.},
  keywords = {},
  booktitle = {},
  journal = {{J}ournal of {V}irology},
  volume = {80},
  numero = {2},
  pages = {605--614},
  ISSN = {0022-538{X}},
  year = {2006},
  DOI = {10.1128/{JVI}.80.2.605-614.2006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010051872},
}