@article{fdi:010050500,
  title = {{M}olecular epidemiology of malaria in {C}ameroon. {XXI}. {B}aseline therapeutic efficacy of chloroquine, amodiaquine, and sulfadoxine-pyrimethamine monotherapies in children before national drug policy change},
  author = {{B}asco, {L}eonardo and {N}gane, {V}.{F}. and {N}dounga, {M}athieu and {S}ame {E}kobo, {A}. and {Y}oumba, {J}.{C}. and {A}bodo, {R}.{T}.{O}. and {S}oula, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he availability of epidemiologic data on drug-resistant malaria based on a standardized clinical and parasitological protocol is a prerequisite for a rational therapeutic strategy to control malaria. {A}s part of the surveillance program on the therapeutic efficacy of the first-line (chloroquine and amodiaquine) and second-line (sulfadoxine-pyrimethamine) drugs for the management of uncomplicated {P}lasmodium fialciparum infections, non-randomized studies were conducted in symptomatic children aged less than 10 years according to the {W}orld {H}ealth {O}rganization protocol (14-day follow-up period) at 12 sentinel sites in {C}ameroon between 1999 and 2004. {O}f 1,407 children enrolled in the studies, 460, 444, and 503 were treated with chloroquine, amodiaquine, or sulfadoxine-pyrimethamine, respectively. {C}hloroquine treatment resulted in high failure rates (proportion of early and late failures, 48.6%). {A}modiaquine was effective at all study sites (proportion of failures, 7.3%). {S}ulfadoxine-pyrimethamine therapy was less effective than amodiaquine ({P} < 0.05), with failures observed in 9.9% of patients. {C}hloroquine is no longer a viable option and has been withdrawn from the official drug outlets in {C}ameroon. {A}modiaquine and, to a lesser extent, sulfadoxine-pyrimethamine monotherapies are still effective in {C}ameroon, but further development of resistance to these drugs should be delayed by the novel strategy using artemisinin-based combination therapy. {O}ur findings indicate that amodiaquine is the most rational partner for artesunate. {S}tudies on the efficacy of artesunate-amodiaquine combination are currently being undertaken at several sites in the country.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {75},
  numero = {3},
  pages = {388--395},
  ISSN = {0002-9637},
  year = {2006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010050500},
}