@article{fdi:010050491,
  title = {{A}n epidemiologic model of the incidence of acute illness in {P}lasmodium falciparum malaria},
  author = {{S}mith, {T}. and {R}oss, {A}. and {M}aire, {N}. and {R}ogier, {C}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {M}olineaux, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e propose a stochastic model for simulating malaria tolerance. {T}he model relates the probability of a clinical attack of malaria to the peripheral parasite densities via a pyrogenic threshold that itself responds dynamically to the parasite load. {T}he parameters of the model have been estimated by fitting it to the relationship between incidence of clinical episodes and the entomologic inoculation rate, using age-specific incidence data from two villages in {S}enegal and one village in {T}anzania. {T}he model reproduces the shifts in age distribution of clinical episodes associated with variation in transmission intensity, and in keeping with the data, predicts a slightly higher lifetime number of episodes in the mesoendemic village of {N}diop than in the holoendemic village of {D}ielmo. {T}his model provides a parsimonious explanation of counter-intuitive relationships between the overall incidence of clinical malaria and transmission intensity. {I}n contrast to the theory of endemic stability, recently proposed to apply to {P}. falciparum, it does not assume any intrinsic age dependence in the outcome of infection. {T}his model can be used to explore the consequences for predictions of the effects of different anti-malarial interventions on the incidence of clinical malaria.},
  keywords = {},
  booktitle = {},
  journal = {{T}he {A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {75},
  numero = {2 {S}uppl. {S}},
  pages = {56--62},
  ISSN = {0002-9637},
  year = {2006},
  DOI = {10.4269/ajtmh.2006.75.56},
  URL = {https://www.documentation.ird.fr/hor/fdi:010050491},
}